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Expression of Candida intermedia GXF1 Improves Xylose Transport in Saccharomyces cerevisiae
This study investigates the heterologous expression of the GXF1 xylose transporter from Candida intermedia in Saccharomyces cerevisiae DTY165. Introduction of GXF1 significantly enhanced xylose uptake, increased intracellular xylose accumulation, and improved cell growth on xylose as the sole carbon source. Despite improved transport, ethanol production remained limited, highlighting that downstream xylose-utilization pathway engineering is also required for meaningful bioethanol yields from lignocellulosic biomass.
Spatio-temporal Assessment of the Bagmati River Water Using Real-Time Data
A comprehensive real-time water quality assessment of the Bagmati River analyzing spatial and temporal variation in key physicochemical and biological parameters. The study provides critical baseline data for understanding river health in the Kathmandu Valley and informs conservation and pollution control strategies for one of Nepal's most iconic river systems.
In vitro Inhibitory Action of Honey Against Extended Spectrum β-Lactamase Producing Escherichia coli and Klebsiella pneumoniae
With antimicrobial resistance on the rise globally, this study examines the in vitro antibacterial efficacy of honey against ESBL-producing clinical isolates of E. coli and K. pneumoniae. Results demonstrate significant inhibitory action, positioning honey as a promising natural adjunct in combating drug-resistant bacterial infections prevalent in Nepal's healthcare settings.
Assessment of In vitro Antidiabetic Activity in Selected Species of Berberis L.
Evaluating the antidiabetic potential of several Berberis species — plants long used in Nepali and South Asian traditional medicine — this study quantifies enzyme inhibitory activity related to glucose metabolism. Findings provide pharmacological validation for traditional use and identify promising candidates for natural anti-hyperglycemic drug development.
Microbial Fuel Cell for Dairy Waste Treatment and Electricity Generation
This innovative study explores microbial fuel cells (MFCs) as a dual-purpose biotechnology: simultaneously treating dairy effluent and generating bioelectricity. Research demonstrates the feasibility of harnessing microbial metabolism to address both environmental pollution from Nepal's dairy industries and the growing demand for decentralized sustainable energy solutions.
In vitro Micropropagation of Endangered Orchid Aerides odorata Lour. from Seed Culture
Aerides odorata, a fragrant and medicinally valued orchid under extinction pressure in Nepal, is the subject of this conservation biotechnology study. A reproducible in vitro seed germination and propagation protocol is successfully developed, offering a scalable approach for mass multiplication and conservation of this endangered Himalayan species.
Detection and Expression of blaKPC-2 and fimH Genes in Klebsiella pneumoniae Clinical Isolates
Addressing the critical challenge of carbapenem-resistant Klebsiella pneumoniae, this study detects and characterizes the carbapenemase gene blaKPC-2 and biofilm-associated virulence gene fimH in clinical isolates. Findings carry direct implications for infection control, antibiotic stewardship, and hospital outbreak management in Nepal's healthcare system.
Isolation and Preliminary Characterization of Fusarium sp. from Diseased Cardamom and Screening of Bacterial Antagonists
Cardamom is one of Nepal's most economically vital spice crops. This study isolates and characterizes Fusarium species responsible for crop disease in cardamom plantations and screens bacterial antagonists as potential biocontrol agents — advancing chemical-free, sustainable disease management for this critical agricultural export.
Cellular Immune Response Evaluation in Nepalese Patients with Cutaneous Leishmaniasis
This study characterizes cellular immune responses in Nepalese patients diagnosed with cutaneous leishmaniasis — a neglected tropical disease with increasing incidence in Nepal's subtropical regions. Detailed immunological profiling advances understanding of disease pathogenesis and supports development of more effective diagnostic and therapeutic strategies in the region.
Screening of Vip Gene in Bacillus thuringiensis Isolated from Different Geographical Areas of Nepal and Vip Protein Effect on Fall Armyworm
Fall armyworm (Spodoptera frugiperda) poses a severe threat to Nepal's food security. This study screens Vegetative insecticidal protein (Vip) genes from locally isolated Bacillus thuringiensis strains collected across varied geographical zones of Nepal and evaluates their toxicity against fall armyworm — advancing biopesticide development from Nepal's own native microbial diversity.
Plant-based Functional Foods from South Asia – Importance and Requirement for Better Healthcare: A Review
South Asia, including Nepal, harbors extraordinary plant biodiversity with deep ethnobotanical traditions. This comprehensive review examines plant-derived bioactive compounds — polyphenols, dietary fiber, and vitamins — incorporated into functional food formulations. With emphasis on Nepal's unique floral heritage, the review makes a compelling case for greater investment in plant-based functional foods to address regional nutrition and public healthcare challenges.
In vitro Antibacterial Activity of Medicinal Plants of Nepal: A Comprehensive Review
Antimicrobial resistance is one of the most urgent global health threats. This systematic review compiles and analyzes published in vitro studies on the antibacterial activity of Nepal's medicinal plants — documenting scientific evidence for plants already embedded in traditional healing systems. An essential reference for researchers, clinicians, and policymakers advocating evidence-based ethnopharmacology in Nepal and South Asia.
https://www.nepalbiotech.org/nba-journal | NepJOL — Vol. 7, No. 1 (2026)
